Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
Disease severity and efficacy of homologous vaccination among patients infected with SARS-CoV-2 Delta or Omicron VOCs, compared to unvaccinated using main biomarkersArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, [키워드] AstraZeneca Biomarker booster case-control study caused Chronic diseases Clinical severity conducted country COVID-19 COVID-19 confirmed patient COVID-19 patient COVID-19 vaccination COVID-19 vaccine CRP level Delta delta variant Delta wave dose doses effective Effectiveness Efficacy expressed females Health homologous homologous vaccination. hospital Hospitalization Hospitalized individual infected with SARS-CoV-2 Iraq Lower males molecular no significant difference no significant effect omicron Omicron variant pandemic Patient patients Pfizer Population Prevent recommendation recorded risk SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant severity significantly Symptom the disease the vaccine transmissibility of SARS-CoV-2 vaccination Vaccine variant variants of concern virus VOCs was done WBC [DOI] 10.1002/jmv.28098 PMC 바로가기
COVID-19 vaccine breakthrough infection among fully vaccinated healthcare workers in Duhok governorate, Iraqi Kurdistan: A retrospective cohort studyArticle Published on 2022-11-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] association Break through infections Breakthrough infection COVID-19 COVID-19 vaccine dentist determine Duhok effective Effectiveness enrolled females fill out fully vaccination HCW HCWs healthcare healthcare worker Healthcare workers highest incidence Infection infections Iraqi Kurdistan majority male Mild moderate MOST multicenter omicron outcomes paramedics participant Pfizer polymerase chain positive postvaccination prevaccination questionnaire random respiratory retrospective cohort study risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant severity significantly the disease the vaccine Vaccine vaccine effectiveness. variant was performed [DOI] 10.1002/jmv.27985 PMC 바로가기
Extended coagulation profile of children with Long Covid: a prospective studyArticle Published on 2022-11-012022-11-16 Journal: Scientific Reports [Category] SARS, 치료기술, [키워드] activated acute SARS-CoV-2 infection Adults age analyzed Antigen Biomarker case-control study change characterized children Coagulation cofactor Cohort control group controls D-dimer level D-dimers Diagnosis eight endothelial damage endotheliopathy enrolled explained Extended females fibrinogen Follow-up FVIII Infection initial International IQR ISARIC Italy Long majority microbiologically no significant difference normalized pediatric plasma profile profiles proportion Prospective Study Prothrombin time respiratory Sample SARS-COV-2 infection Symptom Symptoms the median the SARS-CoV-2 von Willebrand factor vWF [DOI] 10.1038/s41598-022-23168-y PMC 바로가기
COVID-19 and Gut InjuryArticle Published on 2022-10-202022-11-15 Journal: Nutrients [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 bind change children coronavirus COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients death develop disorder females GI Tract Gut high risk host cell IBD increased risk Inflammatory Inflammatory bowel disease inflammatory cell inhibitor Injury mechanism microbiota monoclonal antibody pandemic Pathologies Patient probiotics. receptor recruitment reduce Respiratory system SARS-CoV-2 secreted cytokine severe COVID-19 susceptible Symptom the disease the patient therapeutic option Viral load [DOI] 10.3390/nu14204409 PMC 바로가기
Evaluating diagnostic accuracies of Panbio™ test and RT-PCR for the detection of SARS-CoV-2 in Addis Ababa, Ethiopia using Bayesian Latent-Class Models (BLCM)Article Published on 2022-10-192022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Accuracy Ag-RDTs Bayesian clinical setting cough COVID-19 COVID-19 pandemic CrI criteria cross-sectional diagnostic diagnostic sensitivity diagnostics enrolled evaluate Evaluating exhibited expected females health center hospitals individual majority Model MOST pandemic Patient performed positive positive RT-PCR Rapid rapid antigen test Rapid diagnostic test reference standard reported RT-PCR SARS-CoV-2 sensitivity specificity Study participants symptomatic and asymptomatic the WHO Transmission was done without symptoms [DOI] 10.1371/journal.pone.0268160 PMC 바로가기
Estimation of biochemical factors affecting survival in intensive care COVID-19 patients undergoing chest CT scoring: A retrospective cross-sectional studyArticle Published on 2022-10-072022-11-16 Journal: Medicine [Category] 변종, [키워드] 95% CI Affect affecting age APACHE II APACHE II score approval biochemical Blood urea nitrogen changed Chest computed tomography Chest CT chest CT scan conducted Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Data analysis determine died estimation ethics committee Factor faculty females Follow-up greater Health ICU intensive care Invasive mechanical ventilation laboratory parameter males marker Mortality mortality rate no significant difference nonsurvivor nonsurvivors pandemic Patient PCR PCR test polymerase chain positive Prognosis ranged Respiratory disease Retrospective cross-sectional study significantly SPSS survival survivor symptomatic patient the mean the patient the WHO Transmission university variant was used were recorded widespread window Wuhan [DOI] 10.1097/MD.0000000000030407 PMC 바로가기
Association of Midgut Bacteria and Their Metabolic Pathways with Zika Infection and Insecticide Resistance in Colombian Aedes aegypti PopulationsArticle Published on 2022-10-062022-11-16 Journal: Viruses [Category] 유전자 메커니즘, 치료기술, [키워드] ABC Aede Aedes aegypti affecting analysis Analysis analyzed Bacteria Bacterial Bacteroide changes in Chikungunya Combination condition COVID-19 pandemic Defense Degradation disease Dysbiosis effective evaluated female females function functions generate Honda Host identify Infection infection control infection rate infections infective insecticide insecticides Interaction intestinal intestine knowledge lack lambda-cyhalothrin limitation Local management mechanism metabolic metabolism microbiota microcephaly midgut midgut. modulated Mutation natural infection outbreak pathogenicity Population populations predict predicted prenatal Pseudomona resistance risk RT-PCR significantly sodium South America Surveillance susceptibility susceptible syndrome Transmission Treatment Vaccine vector control Viral transmission virus entry was related Zika Zika virus ZIKV [DOI] 10.3390/v14102197 PMC 바로가기
Vaccine-induced seroconversion in participants in the North Carolina COVID-19 community Research PartnershipArticle Published on 2022-10-062022-11-15 Journal: Vaccine [Category] 진단, [키워드] adjusted hazard ratio Administered Adults BNT162b2 clinical trial Cohort cohort study Community Community study confidence interval COVID-19 COVID-19 vaccine COVID-19 vaccines dose evaluated Evidence feasibility females first vaccination immunogenic Infection less male participant mRNA mRNA-1273 North not affect notable Older participant partnership point-of-care receiving Reporting SARS-CoV-2 SARS-CoV-2 serology. second vaccination Seroconversion seroconversion rate seroconvert serology shown Symptom [DOI] 10.1016/j.vaccine.2022.09.021 PMC 바로가기
Seroepidemiological study of factors affecting anti-spike IgG antibody titers after a two-dose mRNA COVID-19 vaccination in 3744 healthy Japanese volunteersArticle Published on 2022-09-292022-11-15 Journal: Scientific Reports [Category] 진단, [키워드] 1.26 Adverse reaction affecting age anti-S anti-S antibody anti-S IgG anti-Spike IgG antibody Antibody titer Antibody titers BNT162b2 vaccine conducted COVID-19 vaccination cross-sectional dose Effect elapsed Factor Factors female females Gender healthy healthy volunteer identify IgG antibody titer immunosuppressants immunosuppressive IQR Japanese magnitude median age mRNA mRNA-1273 mRNA-1273 vaccine Multiple positive questionnaire SARS-COV-2 infection significantly smoking tested the vaccine therapy vaccination Vaccine Volunteer [DOI] 10.1038/s41598-022-20747-x PMC 바로가기